2009, discovery of a new phenotype for germs in slim nanofluidic slits; and 1st detection of community protein buildings alongside DNA working with good-point out nanopores
But how can morality, the dignity in the human being, my practical experience on the which means of life, adhere to within the motion of atoms? A purely naturalistic perspective fails in this article; a Christian viewpoint, I think, is a way more sensible way to interpret these areas of actuality.’
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Non-equilibrium folding of particular person DNA molecules recaptured around 1000 periods within a solid condition nanopore
This yielded a breakthrough. Inside just a few months, we ended up able to measure transport by way of somebody single-walled carbon nanotube. Depending on very low-temperature experiments by a superb PhD student in my group, Sander Tans (now a valued colleague and professor at Delft University of Engineering using an Lively investigate lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes were genuine quantum wires with really prolonged (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic conduct.
Case in point (3) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is revealed in grey, the rim in the pore is highlighted in pink, along with a 3D rendering on the movement from the DNA rod is shown.
We use nanofabricated microfluidic buildings to pattern spatial boundaries for bacteria and biomimetic vesicles with reconstituted protein networks which assess the elemental part of spatial confinement in the molecular and mobile degree. Our projects include things like the next:
2011, initial in vitro measurements of transportation throughout just one biomimetic nuclear pore advanced; improvement of multiplexed magnetic tweezers for kilo-molecule experiments; and solved the mechanism of homology recognition in DNA homologous recombination
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There was one challenge however — we did not notice any measurable electrical conduction from The only polymer molecules. We concluded that at The one-molecule stage, conducting polymers had been basically not these excellent conductors, which was rather disappointing. We So broadened our look at to try to search out a lot more promising molecules.
Testing pseudotopological and nontopological versions for SMC-driven DNA loop extrusion from roadblock-traversal experiments
Nanoscientist Cees Dekker is undoubtedly an amiable and flamboyant guy who seems Considerably younger than the sixty two many ceesdekker.net years he basically is – stylish glasses, psychedelic shirt, partaking smile – but not just one to waste time. He takes his time, but no more than necessary.
2008, first observation of protein-coated DNA translocation as a result of nanopores; fixed the origin on the electrophoretic power on DNA in nanopores; found an important velocity raise of microtubules in electrical fields; identified an anomalous electro-hydrodynamic orientation of microtubules; and resolved the origin of sounds in carbon nanotubes in liquid
Supercoiling-dependent DNA binding: quantitative modeling and purposes to bulk and solitary-molecule experiments